Explainers
What is an orexin agonist?
Orexin agonists switch on the brain receptor for the neuropeptide that holds wakefulness stable. What the class is, where it came from, why it matters.
Narcolepsy type 1
Narcolepsy type 1 is caused by destruction of the brain's orexin neurons. What that does, how it is diagnosed, and why this drug class was built for it.
Narcolepsy type 2 and idiopathic hypersomnia
Patients with narcolepsy type 2 and idiopathic hypersomnia are not orexin-deficient, yet agonists are tested in both. Why, and what rides on the answer.
Orexin agonists vs orexin antagonists
Suvorexant and daridorexant are orexin antagonists for insomnia. Oveporexton is an agonist for sleepiness. The names look alike; they do opposite things.
Orexin agonists vs current narcolepsy treatments
Existing narcolepsy treatments work around the missing orexin signal. This class targets it directly. What that difference means, and what is unknown.
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