{
  "fetched": "2026-08-04",
  "source": "ClinicalTrials.gov API v2",
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      {
        "nct": "NCT07455383",
        "title": "A Study to Evaluate the Efficacy and Safety of ALKS 2680 in Adults With Narcolepsy Type 1",
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      {
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      {
        "nct": "NCT06767683",
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      {
        "nct": "NCT06555783",
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      {
        "nct": "NCT06358950",
        "title": "A Study to Evaluate the Safety and Effectiveness of ALKS 2680 in Subjects With Narcolepsy Type 1 (ALKS 2680-201)",
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        "nct": "NCT07598708",
        "title": "A Study to Investigate the Effects of Cleminorexton Compared With Placebo in the Treatment of Participants With Central Disorders of Hypersomnolence",
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      {
        "nct": "NCT07096674",
        "title": "A Long-term Extension Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia",
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      {
        "nct": "NCT06752668",
        "title": "A Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia",
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      {
        "nct": "NCT07646678",
        "title": "A Study of TAK-360 in People With Narcolepsy or Idiopathic Hypersomnia",
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      {
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      {
        "nct": "NCT06952699",
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      {
        "nct": "NCT06812078",
        "title": "A Study of TAK-360 in Adults With Idiopathic Hypersomnia",
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        "lastUpdate": "2026-07-15"
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    ],
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      {
        "nct": "NCT07493265",
        "title": "A Study to Evaluate the Efficacy and Safety of E2086 in Adults With Narcolepsy",
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        "phase": "Phase 2",
        "sponsor": "Eisai Inc.",
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        "conditions": [
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        "lastUpdate": "2026-05-14"
      },
      {
        "nct": "NCT07308236",
        "title": "A Study to Determine the Metabolism and Excretion of [14C]E2086 in Healthy Male Participants",
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        "phase": "Phase 1",
        "sponsor": "Eisai Inc.",
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        "conditions": [
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        "start": "2025-12-31",
        "primaryCompletion": "2026-02-23",
        "completion": "2026-02-23",
        "lastUpdate": "2026-03-05"
      },
      {
        "nct": "NCT06481488",
        "title": "A Study of E2086 in Healthy Adult Participants",
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        "phase": "Phase 1",
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        "conditions": [
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        "lastUpdate": "2025-01-16"
      },
      {
        "nct": "NCT06462404",
        "title": "A Study to Evaluate the Efficacy, Safety, and Tolerability of E2086 Compared to Placebo and Active Comparator in Adult Participants With Narcolepsy Type 1",
        "status": "Completed",
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        "phase": "Phase 1",
        "sponsor": "Eisai Inc.",
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        "conditions": [
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        "start": "2024-06-20",
        "primaryCompletion": "2025-03-17",
        "completion": "2025-03-17",
        "lastUpdate": "2025-06-04"
      },
      {
        "nct": "NCT05745207",
        "title": "A Study To Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E2086 in Healthy Adult and Elderly Participants",
        "status": "Completed",
        "statusCode": "COMPLETED",
        "phase": "Phase 1",
        "sponsor": "Eisai Inc.",
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        "conditions": [
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        "start": "2023-02-20",
        "primaryCompletion": "2024-01-18",
        "completion": "2024-01-18",
        "lastUpdate": "2024-10-02"
      }
    ],
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      {
        "nct": "NCT07082829",
        "title": "A Study of ORX142 in Healthy Adult Subjects, Including Subjects 18 to 80 Years of Age",
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        "statusCode": "RECRUITING",
        "phase": "Phase 1",
        "sponsor": "Centessa Pharmaceuticals (UK) Limited",
        "enrollment": 208,
        "conditions": [
          "Excessive Daytime Sleepiness"
        ],
        "start": "2025-06-30",
        "primaryCompletion": "2026-06-15",
        "completion": "2026-06-15",
        "lastUpdate": "2025-12-24"
      }
    ],
    "orx489": [
      {
        "nct": "NCT07413666",
        "title": "A Study of ORX489 in Healthy Adult Participants, Aged 18 to 60 Years",
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        "statusCode": "RECRUITING",
        "phase": "Phase 1",
        "sponsor": "Centessa Pharmaceuticals (UK) Limited",
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        "conditions": [
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        "start": "2026-02-25",
        "primaryCompletion": "2027-06-30",
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        "lastUpdate": "2026-02-25"
      }
    ],
    "alks-4510": [],
    "alks-7290": [],
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      {
        "nct": "NCT04820842",
        "title": "A Study of TAK-994 in Adults With Narcolepsy",
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        "phase": "Phase 2",
        "sponsor": "Takeda",
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        "conditions": [
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        "start": "2021-04-30",
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        "completion": "2021-11-03",
        "lastUpdate": "2023-12-26"
      },
      {
        "nct": "NCT04833049",
        "title": "Study to Evaluate Absorption, Metabolism, and Excretion, of TAK-994 in 6 Healthy Male Adults",
        "status": "Completed",
        "statusCode": "COMPLETED",
        "phase": "Phase 1",
        "sponsor": "Takeda",
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        "primaryCompletion": "2021-06-20",
        "completion": "2021-06-20",
        "lastUpdate": "2021-06-29"
      },
      {
        "nct": "NCT04745767",
        "title": "A Study of Different Forms of TAK-994 in Healthy Adults",
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        "statusCode": "COMPLETED",
        "phase": "Phase 1",
        "sponsor": "Takeda",
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        "conditions": [
          "Healthy Participants"
        ],
        "start": "2021-02-16",
        "primaryCompletion": "2021-03-25",
        "completion": "2021-04-05",
        "lastUpdate": "2021-04-22"
      },
      {
        "nct": "NCT04551079",
        "title": "A Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics (PK) of Oral TAK-994 in an Acute Sleep Phase Delay Paradigm in Healthy Male Participants",
        "status": "Completed",
        "statusCode": "COMPLETED",
        "phase": "Phase 1",
        "sponsor": "Takeda",
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        "conditions": [
          "Healthy Volunteers"
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        "start": "2020-09-23",
        "primaryCompletion": "2020-12-31",
        "completion": "2020-12-31",
        "lastUpdate": "2021-01-19"
      },
      {
        "nct": "NCT04096560",
        "title": "A Study of TAK-994 in Adults With Type 1 and Type 2 Narcolepsy",
        "status": "Terminated",
        "statusCode": "TERMINATED",
        "phase": "Phase 2",
        "sponsor": "Takeda",
        "enrollment": 97,
        "conditions": [
          "Narcolepsy Type 1 (NT1)",
          "Narcolepsy Type 2 (NT2)"
        ],
        "start": "2020-05-27",
        "primaryCompletion": "2021-11-05",
        "completion": "2021-11-05",
        "lastUpdate": "2024-10-29"
      },
      {
        "nct": "NCT03933488",
        "title": "A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of TAK-994 in Healthy Participants",
        "status": "Completed",
        "statusCode": "COMPLETED",
        "phase": "Phase 1",
        "sponsor": "Takeda",
        "enrollment": 121,
        "conditions": [
          "Healthy Participants"
        ],
        "start": "2019-05-01",
        "primaryCompletion": "2020-03-29",
        "completion": "2020-03-29",
        "lastUpdate": "2020-06-24"
      }
    ],
    "danavorexton": [
      {
        "nct": "NCT05814016",
        "title": "A Study of Danavorexton in People With Obstructive Sleep Apnea After General Anesthesia for Abdominal Surgery",
        "status": "Terminated",
        "statusCode": "TERMINATED",
        "phase": "Phase 2",
        "sponsor": "Takeda",
        "enrollment": 41,
        "conditions": [
          "Sleep Apnea"
        ],
        "start": "2023-05-11",
        "primaryCompletion": "2024-09-25",
        "completion": "2024-09-25",
        "lastUpdate": "2025-09-16"
      },
      {
        "nct": "NCT05180890",
        "title": "A Study of Danavorexton (TAK-925) in Adults With Obstructive Sleep Apnea",
        "status": "Completed",
        "statusCode": "COMPLETED",
        "phase": "Phase 1",
        "sponsor": "Takeda",
        "enrollment": 13,
        "conditions": [
          "Sleep Apnea"
        ],
        "start": "2022-03-10",
        "primaryCompletion": "2022-11-23",
        "completion": "2022-11-23",
        "lastUpdate": "2022-12-02"
      },
      {
        "nct": "NCT05025397",
        "title": "A Study of Danavorexton in Anesthetized Adults",
        "status": "Completed",
        "statusCode": "COMPLETED",
        "phase": "Phase 1",
        "sponsor": "Takeda",
        "enrollment": 28,
        "conditions": [
          "Healthy Volunteers"
        ],
        "start": "2021-09-28",
        "primaryCompletion": "2022-03-08",
        "completion": "2022-03-08",
        "lastUpdate": "2022-05-10"
      },
      {
        "nct": "NCT04091438",
        "title": "A Study of a Single Intravenous Infusion Dose of TAK-925 in Participants With Idiopathic Hypersomnia",
        "status": "Completed",
        "statusCode": "COMPLETED",
        "phase": "Phase 1",
        "sponsor": "Millennium Pharmaceuticals, Inc.",
        "enrollment": 28,
        "conditions": [
          "Idiopathic Hypersomnia"
        ],
        "start": "2020-01-26",
        "primaryCompletion": "2020-11-19",
        "completion": "2020-11-23",
        "lastUpdate": "2023-09-26"
      },
      {
        "nct": "NCT04091425",
        "title": "Study of TAK-925 in Participants With Obstructive Sleep Apnea (OSA) Who Are Experiencing Excessive Daytime Sleepiness (EDS) Despite Adequate Use of Continuous Positive Airway Pressure (CPAP)",
        "status": "Completed",
        "statusCode": "COMPLETED",
        "phase": "Phase 1",
        "sponsor": "Millennium Pharmaceuticals, Inc.",
        "enrollment": 25,
        "conditions": [
          "Obstructive Sleep Apnea"
        ],
        "start": "2019-11-21",
        "primaryCompletion": "2020-04-02",
        "completion": "2020-04-02",
        "lastUpdate": "2020-04-20"
      },
      {
        "nct": "NCT03748979",
        "title": "A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of TAK-925 in Healthy Volunteers and Participants With Narcolepsy",
        "status": "Completed",
        "statusCode": "COMPLETED",
        "phase": "Phase 1",
        "sponsor": "Takeda",
        "enrollment": 57,
        "conditions": [
          "Healthy Participants",
          "Narcolepsy"
        ],
        "start": "2018-11-21",
        "primaryCompletion": "2019-10-24",
        "completion": "2019-10-24",
        "lastUpdate": "2020-12-08"
      },
      {
        "nct": "NCT03522506",
        "title": "A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of TAK-925 Study in Sleep-Deprived Healthy Adults",
        "status": "Completed",
        "statusCode": "COMPLETED",
        "phase": "Phase 1",
        "sponsor": "Takeda",
        "enrollment": 20,
        "conditions": [
          "Healthy Volunteers"
        ],
        "start": "2018-05-09",
        "primaryCompletion": "2018-11-07",
        "completion": "2018-11-07",
        "lastUpdate": "2021-03-26"
      },
      {
        "nct": "NCT03332784",
        "title": "Phase 1 TAK-925 Study in Healthy Adult and Elderly Volunteers and Participants With Narcolepsy",
        "status": "Completed",
        "statusCode": "COMPLETED",
        "phase": "Phase 1",
        "sponsor": "Takeda",
        "enrollment": 58,
        "conditions": [
          "Healthy Participants and Patients With Narcolepsy"
        ],
        "start": "2017-11-04",
        "primaryCompletion": "2018-09-04",
        "completion": "2018-09-04",
        "lastUpdate": "2021-03-30"
      }
    ],
    "jzp441": [
      {
        "nct": "NCT06961266",
        "title": "A Study to Investigate Efficacy, Safety, Tolerability, and Pharmacokinetics of JZP441 Compared With Placebo in Participants With Narcolepsy Type 1",
        "status": "Terminated",
        "statusCode": "TERMINATED",
        "phase": "Phase 1",
        "sponsor": "Jazz Pharmaceuticals",
        "enrollment": 6,
        "conditions": [
          "Narcolepsy"
        ],
        "start": "2025-05-13",
        "primaryCompletion": "2026-01-29",
        "completion": "2026-01-29",
        "lastUpdate": "2026-04-06"
      },
      {
        "nct": "NCT05720494",
        "title": "A Multiple Ascending Dose Study to Investigate the Safety, Tolerability, and Pharmacokinetics of JZP441 in Healthy Participants",
        "status": "Completed",
        "statusCode": "COMPLETED",
        "phase": "Phase 1",
        "sponsor": "Jazz Pharmaceuticals",
        "enrollment": 24,
        "conditions": [
          "Healthy Participants"
        ],
        "start": "2023-01-26",
        "primaryCompletion": "2023-09-29",
        "completion": "2023-09-29",
        "lastUpdate": "2024-10-01"
      },
      {
        "nct": "NCT05651152",
        "title": "A Study to Investigate The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of JZP441 in Sleep-deprived Healthy Participants",
        "status": "Completed",
        "statusCode": "COMPLETED",
        "phase": "Phase 1",
        "sponsor": "Jazz Pharmaceuticals",
        "enrollment": 105,
        "conditions": [
          "Healthy Participants"
        ],
        "start": "2022-11-28",
        "primaryCompletion": "2023-11-15",
        "completion": "2023-11-15",
        "lastUpdate": "2024-07-30"
      }
    ]
  }
}